Synthesis and Characterization of Cerium Oxide Nanoparticles: Effect of Cerium Precursor to Gelatin Ratio

Hemocompatible nanoparticles with reactive oxygen species (ROS) scavenging properties for titanium implant surface coatings may eliminate failure related to inflammation and bacterial invasion. Cerium (Ce) is a rare earth element, that belongs the lanthanide group. It exists in two oxidation states, Ce+3 Ce+4, which contribute antioxidant, catalytic, antibacterial, ROS-scavenging properties. The purpose of present study was synthesize ceria evaluate their hemocompatibility ROS synthesis Ce-NPs performed via sol-gel method, five different ratios cerium precursors gelatin were evaluated. Their characterization achieved through FTIR, XRD, SEM, TEM. Hemocompatibility analysis evaluated at concentrations human erythrocytes. morphology size distribution certified by TEM cubic CeO2 fluorite structure identified selected area electron diffraction high-resolution particle lowest Ce concentration presented mean diameter 10 nm. At <500 μg/mL, no hemolytic effect observed. highest concentrations, behavior recorded samples precursor, also (10–50% reduction ROS). These make those NPs unique candidates as nanofillers or nanocoatings antibacterial